Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14817907 | 0.85 | ROCK2 (0.52) | ROCK2FPR2KDM4ENAMPTMAPT | |
| SCHEMBL31188529 | 0.85 | GAA (0.60) | ROCK2FPR2KDM4EMAPTGAA | |
| SCHEMBL7011089 | 0.83 | NAMPT (0.65) | NAMPT | |
| SCHEMBL18617522 | 0.83 | ROCK2 (0.50) | ROCK2FPR2NAMPTADORA3ADORA2A | |
| SCHEMBL20671963 | 0.82 | ROCK2 (0.47) | ROCK2FPR2MAPTADORA3ADORA2A | |
| SCHEMBL3769508 | 0.82 | ROCK2 (0.49) | ROCK2FPR2KDM4ENAMPTADORA3 | |
| SCHEMBL21335657 | 0.81 | PLK1 (0.50) | ROCK2FPR2KDM4ENAMPTADORA3 | |
| SCHEMBL31680532 | 0.81 | TAAR1 (0.55) | ROCK2FPR2KDM4ENAMPTMAPT | |
| SCHEMBL6451096 | 0.77 | FPR2 (0.55) | ROCK2FPR2KDM4EADORA3ADORA2A | |
| SCHEMBL1258259 | 0.76 | FPR2 (0.54) | ROCK2FPR2ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343303-A1 | PI3-kinase inhibitors | Boehringer Ingelheim International GmbH (DE) | 2011-07-13 | — | — | EP | disclosed |