Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.57 |
| ▸ | ALOX5AP | P20292 | 7/20 | 0.40 |
| ▸ | FEN1 | P39748 | 7/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12462643 | 0.85 | RET (0.49) | GRM5ALOX5APFEN1DYRK1ADYRK1B | |
| SCHEMBL12462373 | 0.76 | GRM5 (0.44) | GRM5ALOX5APFEN1DYRK1AADRA2A | |
| SCHEMBL12461953 | 0.74 | GRM5 (0.57) | GRM5ALOX5APFEN1 | |
| SCHEMBL12507352 | 0.70 | PDGFRB (0.51) | GRM5KDRTEK | |
| SCHEMBL13139105 | 0.69 | ADRA2A (0.51) | GRM5ADRA2AADRA2BADRA2C | |
| SCHEMBL12462547 | 0.68 | GRM5 (0.39) | GRM5ALOX5APFEN1ADRA2AADRA2B | |
| SCHEMBL14435643 | 0.67 | LTA4H (0.63) | ERBB2KDRSCN5ASCN9ATEK | |
| SCHEMBL17948198 | 0.67 | LTA4H (0.63) | ERBB2KDRSCN5ASCN9ATEK | |
| SCHEMBL12462321 | 0.67 | GRM5 (0.45) | GRM5ALOX5APFEN1 | |
| SCHEMBL7514685 | 0.66 | ALDH1A1 (0.65) | ERBB2KDRSCN5ASCN9ATEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341052-A1 | RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-07-06 | — | — | EP | disclosed |