Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 11/20 | 0.48 |
| ▸ | GAK | O14976 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | CARS1 | P49589 | 1/20 | 0.46 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.46 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.46 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.46 |
| ▸ | TDO2 | P48775 | 3/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21382644 | 0.77 | GRM5 (0.65) | GRM5EGFRALOX5APFEN1 | |
| SCHEMBL12462373 | 0.75 | GRM5 (0.44) | GRM5ALOX5APFEN1 | |
| SCHEMBL12462022 | 0.73 | GRM5 (0.57) | GRM5ALOX5APFEN1KDR | |
| SCHEMBL12462643 | 0.72 | RET (0.49) | GRM5ALOX5APFEN1 | |
| SCHEMBL15928191 | 0.71 | EGFR (0.76) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL12507810 | 0.70 | GRM5 (0.46) | GRM5EGFRGAKRIPK2BUB1 | |
| SCHEMBL12461953 | 0.68 | GRM5 (0.57) | GRM5ALOX5APFEN1PDGFRB | |
| SCHEMBL13139105 | 0.68 | ADRA2A (0.51) | GRM5 | |
| SCHEMBL28907418 | 0.67 | EGFR (0.73) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL14376061 | 0.67 | GRM5 (0.67) | GRM5ALOX5APFEN1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2341052-A1 | RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-07-06 | — | — | EP | disclosed |