Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917420 | 0.81 | GLP1R (0.46) | KDM4EMAPK1CLK4IRAK4STK17B | |
| SCHEMBL14112779 | 0.79 | KDM4E (0.45) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL1938460 | 0.78 | STK17A (0.51) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL5419429 | 0.76 | XDH (0.39) | KDM4EALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL11908962 | 0.76 | ALDH1A1 (0.59) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL2817011 | 0.76 | HTT (0.41) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL1774700 | 0.76 | KMT2A (0.43) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL25902572 | 0.75 | HTT (0.58) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL25902576 | 0.73 | HTT (0.40) | HTTKDM4EMAPK1STK17BSTK17A | |
| SCHEMBL27502303 | 0.72 | CSNK1A1 (0.51) | HTTKDM4EMAPK1AURKACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011080568-A2 | NOVEL PYRIMIDINE COMPOUNDS AS MTOR AND P13K INHIBITORS | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2011-07-07 | — | — | WO | disclosed |