Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12463147 | 0.76 | HTT (0.42) | KDM4EALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL1917685 | 0.75 | KDM4E (0.33) | KDM4EALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL4535369 | 0.75 | LRRK2 (0.51) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL30337436 | 0.75 | KDM4E (0.33) | KDM4EALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL6457831 | 0.74 | XDH (0.42) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL2265828 | 0.72 | XDH (0.41) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL3139282 | 0.72 | KMT2A (0.49) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL4534881 | 0.72 | ALDH1A1 (0.54) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL3644211 | 0.72 | XDH (0.41) | XDHYTHDC1PDE2ALRRK2JAK2 | |
| SCHEMBL16914307 | 0.72 | S100A9 (0.45) | XDHYTHDC1PDE2ALRRK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | XDH 152/4885YTHDC1 1268/4885PDE2A 2545/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | XDH 81/4885YTHDC1 1094/4885PDE2A 2080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.