Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | F12 | P00748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14886275 | 0.84 | PLAU (0.33) | PLAU | |
| SCHEMBL12824216 | 0.83 | TPMT (0.34) | — | |
| SCHEMBL10140987 | 0.80 | PLAU (0.32) | PLAUF2PLGKLKB1KLK1 | |
| SCHEMBL7949112 | 0.65 | LCK (0.62) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL1297632 | 0.64 | NOS1 (0.44) | — | |
| SCHEMBL29644321 | 0.64 | NOS1 (0.44) | — | |
| SCHEMBL12824214 | 0.64 | — | — | |
| SCHEMBL16923685 | 0.63 | TPMT (0.38) | — | |
| SCHEMBL852419 | 0.63 | TPMT (0.60) | — | |
| SCHEMBL10713877 | 0.61 | NOS1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011081918-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011031934-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |