Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.69 |
| ▸ | MMP14 | P50281 | 5/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.69 |
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819075 | 1.00 | MMP13 (0.69) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL4810937 | 0.92 | MMP13 (0.57) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463373 | 0.89 | MMP13 (0.54) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463353 | 0.89 | MMP13 (0.54) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463628 | 0.88 | MMP13 (0.62) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463853 | 0.86 | CYP3A4 (0.54) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463342 | 0.85 | MMP13 (0.59) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463852 | 0.85 | MMP13 (0.62) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL12463700 | 0.85 | MMP13 (0.53) | MMP13MMP14CYP3A4ADAMTS4KCNH2 | |
| SCHEMBL14252784 | 0.85 | MMP13 (0.63) | MMP13MMP14CYP3A4ADAMTS4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973039-B2 | 3-(1,3-benzodioxol-5-yl)-1-({[4-(4-fluorophenyl)-1-piperazinyl]sulfonyl}methyl)-2-propynyl(hydroxy)formamide; analgesics, anticarcinogenic agents, antiarthritic agents; matrix metalloproteinase inhhibitors | MERCK SERONO SA (CH) | 2011-07-05 | — | — | US | disclosed |
| US-20080194520-A1 | Sulfonyl Amino Cyclic Derivatives and Use Thereof | MERCK SERONO SA (CH) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194520-A1 | Sulfonyl Amino Cyclic Derivatives and Use Thereof | GLS2, SRM, GLS | MMP13 2288/4885MMP14 2295/4885CYP3A4 1396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.