Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PTPRF | P10586 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2244516 | 0.92 | CYP2E1 (0.40) | KDM4EHTTATMCHEK1ALDH1A1 | |
| SCHEMBL12464670 | 0.90 | KDM4E (0.38) | KDM4EHTTATMRAB9APTPRF | |
| SCHEMBL12464664 | 0.88 | PTPRF (0.35) | KDM4EHTTATMPTPRFPTPN1 | |
| SCHEMBL14865845 | 0.87 | CHEK1 (0.35) | KDM4EHTTATMCHEK1PTPRF | |
| SCHEMBL12464440 | 0.87 | MKNK1 (0.40) | KDM4EHTTATM | |
| SCHEMBL13355742 | 0.86 | CHEK1 (0.35) | KDM4EHTTATMCHEK1ALDH1A1 | |
| SCHEMBL2876272 | 0.86 | CHEK1 (0.35) | KDM4EHTTATMCHEK1ALDH1A1 | |
| SCHEMBL2878321 | 0.84 | KDM4E (0.42) | KDM4EHTTATMPTPRFPTPN1 | |
| SCHEMBL17635079 | 0.84 | KDM4E (0.42) | KDM4EHTTATMPTPRFPTPN1 | |
| SCHEMBL14291007 | 0.82 | KDM4E (0.50) | KDM4EHTTATMCHEK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |