Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157845 | 0.90 | LTB4R2 (0.48) | NR1H4LTB4R2KMT2A | |
| SCHEMBL2157679 | 0.90 | NR1H4 (0.47) | NR1H4LTB4R2TSPOHTTMEN1 | |
| SCHEMBL2158067 | 0.88 | NR1H4 (0.52) | NR1H4LTB4R2MEN1KMT2APTGES | |
| SCHEMBL12464572 | 0.87 | LTB4R2 (0.46) | NR1H4LTB4R2PTGES | |
| SCHEMBL2158851 | 0.85 | LTB4R2 (0.48) | LTB4R2TSPOHTTMEN1KMT2A | |
| SCHEMBL12464236 | 0.82 | CPB1 (0.51) | NR1H4TSPOHTTMEN1KMT2A | |
| SCHEMBL2158539 | 0.81 | ALDH1A1 (0.41) | NR1H4LTB4R2ALDH1A1 | |
| SCHEMBL2158059 | 0.79 | RIPK1 (0.40) | NR1H4LTB4R2MEN1KMT2AALDH1A1 | |
| SCHEMBL2158746 | 0.79 | LTB4R2 (0.52) | LTB4R2TSPOHTTMEN1KMT2A | |
| SCHEMBL3812537 | 0.77 | LTB4R2 (0.45) | NR1H4LTB4R2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985769-B2 | Compounds and methods for the treatment or prevention of Flavivirus infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |