Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 6/20 | 0.39 |
| ▸ | ACE | P12821 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8016966 | 1.00 | MME (0.39) | MMEACECA12CA1CA2 | |
| SCHEMBL20326558 | 0.88 | CA1 (0.45) | CA12CA1CA2CA9CA14 | |
| SCHEMBL8030419 | 0.83 | CA14 (0.35) | CA12CA1CA2CA9CA14 | |
| SCHEMBL28463509 | 0.80 | CA14 (0.35) | CA14 | |
| SCHEMBL28463510 | 0.80 | CA14 (0.35) | CA14 | |
| SCHEMBL2862223 | 0.79 | CA1 (0.38) | CA12CA1CA2CA9CA14 | |
| SCHEMBL19750797 | 0.79 | CA1 (0.41) | CA12CA1CA2CA9CA14 | |
| SCHEMBL21877076 | 0.78 | CA14 (0.39) | CA12CA1CA2CA14HDAC1 | |
| SCHEMBL20315020 | 0.77 | CA14 (0.40) | CA12CA1CA2CA9CA14 | |
| SCHEMBL14750621 | 0.77 | MEN1 (0.34) | CA12CA1CA2CA14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298754-B9 | Preparation of taxane derivatives | INDENA SPA (IT) | 2013-12-18 | — | — | EP | disclosed |
| EP-2298754-B1 | Preparation of taxane derivatives | INDENA SPA (IT) | 2013-08-07 | — | — | EP | disclosed |
| EP-2264019-B1 | Intermediates for the preparation of taxane derivatives | INDENA SPA (IT) | 2013-07-24 | — | — | EP | disclosed |
| EP-2077264-B1 | Taxane derivatives and a process for the preparation thereof | INDENA SPA (IT) | 2012-11-14 | — | — | EP | disclosed |
| EP-2298754-A1 | Preparation of taxane derivatives | Indena S.p.A. (IT) | 2011-03-23 | — | — | EP | disclosed |
| EP-2281820-A2 | Taxane derivatives and a process for the preparation thereof | Indena S.p.A. (IT) | 2011-02-09 | — | — | EP | disclosed |
| EP-2264019-A1 | Intermediates fot the preparation of taxane derivatives | Indena S.p.A. (IT) | 2010-12-22 | — | — | EP | disclosed |
| EP-2077264-A2 | Taxane derivatives and a process for the preparation thereof | INDENA S.p.A. (IT) | 2009-07-08 | — | — | EP | disclosed |
| US-7498452-B2 | Taxane derivatives functionalized at the 14-position and a process for the preparation thereof | INDENA S.P.A. (IT) | 2009-03-03 | — | — | US | disclosed |
| EP-1980557-A2 | Taxane derivatives functionalized at the 14-position and a process for the preparation thereof | Indena S.P.A. (IT) | 2008-10-15 | — | — | EP | disclosed |
| EP-1537093-B1 | TAXANE DERIVATIVES FUNCTIONALIZED AT THE 14- POSITION AND A PROCESS FOR THE PREPARATION THEREOF | INDENA SPA (IT) | 2008-06-11 | — | — | EP | disclosed |
| US-20060122258-A1 | Taxane derivatives functionalized at the 14-position and a process for the preparation thereof | INDENA S.P.A. (IT) | 2006-06-08 | — | — | US | disclosed |
| CN-1681799-A | Taxane derivatives functionalized at the 14- position and a process for the preparation thereof | INDENA SPA (IT) | 2005-10-12 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122258-A1 | Taxane derivatives functionalized at the 14-position and a process for the preparation thereof | TUBA1B, TUBB2B, TUBB3 | MME 4597/4885ACE 3840/4885CA12 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.