SCHEMBL12465697

SCHEMBL12465697

CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(-c3ccc(F)cc3)c(C(=O)c3cccc(F)c3)s2)cc1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.82
RORB Q92753 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12468543 0.93 RORC (0.87) RORCRORB
SCHEMBL12465747 0.90 RORC (1.00) RORCRORB
SCHEMBL12467562 0.89 RORC (0.84) RORCRORB
SCHEMBL12465759 0.87 RORC (0.85) RORC
SCHEMBL12465641 0.86 RORC (0.85) RORCRORB
SCHEMBL12467542 0.86 RORC (1.00) RORCRORB
SCHEMBL12465750 0.85 RORC (0.80) RORCRORB
SCHEMBL12467550 0.83 RORC (1.00) RORCRORB
SCHEMBL12465952 0.83 RORC (0.87) RORCRORB
SCHEMBL12467544 0.82 RORC (0.78) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012100732-A1 RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS, COMPOSITION CONTAINING THEM AND USES THEREOF GLAXO GROUP LIMITED (GB) 2012-08-02 WO disclosed