SCHEMBL12465759

SCHEMBL12465759

CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(-c3cccc(C#N)c3)c(C(=O)c3cccc(F)c3)s2)cc1

nearest known ligand 0.85

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12467638 0.93 RORC (0.72) RORC
SCHEMBL12465747 0.88 RORC (1.00) RORC
SCHEMBL12465697 0.87 RORC (0.82) RORC
SCHEMBL12467562 0.87 RORC (0.84) RORC
SCHEMBL12465760 0.85 RORC (0.82) RORC
SCHEMBL12466155 0.83 RORC (0.84) RORC
SCHEMBL12467550 0.82 RORC (1.00) RORC
SCHEMBL12465641 0.81 RORC (0.85) RORC
SCHEMBL12467542 0.81 RORC (1.00) RORC
SCHEMBL12465942 0.80 RORC (0.86) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012100732-A1 RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS, COMPOSITION CONTAINING THEM AND USES THEREOF GLAXO GROUP LIMITED (GB) 2012-08-02 WO disclosed