Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | EPRS1 | P07814 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15489226 | 0.89 | AURKA (0.40) | MCL1AHRRXFP1MEN1MAPT | |
| SCHEMBL28573139 | 0.86 | LDHA (0.44) | MAPTSMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL12465730 | 0.82 | MAPT (0.53) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL12687780 | 0.78 | MC4R (0.39) | — | |
| SCHEMBL3076452 | 0.74 | KDM5A (0.41) | KDM5AKDM4CKDM5BMEN1MAPT | |
| SCHEMBL2031842 | 0.73 | KMO (0.44) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL31309497 | 0.72 | HCAR3 (0.38) | KDM4C | |
| SCHEMBL31288913 | 0.71 | NR4A2 (0.47) | MEN1MAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2033721 | 0.71 | AHR (0.40) | AHRMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2030860 | 0.71 | KMT2A (0.41) | MCL1AHRPTPN1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493456-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | UNIVERSITE DE MONTREAL (CA) | 2016-11-15 | — | — | US | disclosed |
| US-9493456-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | UNIVERSITE DE MONTREAL (CA) | 2016-11-15 | — | — | US | disclosed |
| US-9493456-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | UNIVERSITE DE MONTREAL (CA) | 2016-11-15 | — | — | US | disclosed |
| US-20150197520-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal | 2015-07-16 | — | — | US | disclosed |
| US-20150197520-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal | 2015-07-16 | — | — | US | disclosed |
| US-20150197520-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal | 2015-07-16 | — | — | US | disclosed |
| US-9018395-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | Université de Montréal (CA) | 2015-04-28 | — | — | US | disclosed |
| US-9018395-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | Université de Montréal (CA) | 2015-04-28 | — | — | US | disclosed |
| US-9018395-B2 | Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators | Université de Montréal (CA) | 2015-04-28 | — | — | US | disclosed |
| US-20140057894-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2014-02-27 | — | — | US | disclosed |
| US-20140057894-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2014-02-27 | — | — | US | disclosed |
| US-20140057894-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | UNIVERSITE DE MONTREAL (CA) | 2014-02-27 | — | — | US | disclosed |
| WO-2012100342-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012100342-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | Université de Montréal (CA) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150197520-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC1R | MCL1 3208/4885KDM5A 1084/4885KDM4C 969/4885 |
| US-20140057894-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MC4R, MC5R, MC1R | MCL1 2745/4885KDM5A 1278/4885KDM4C 1238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.