Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.44 |
| ▸ | RARB | P10826 | 4/20 | 0.44 |
| ▸ | RARG | P13631 | 4/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HNF4A | P41235 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10555380 | 0.82 | RARA (0.44) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL12715255 | 0.79 | RARA (0.46) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL3819800 | 0.79 | RXRA (0.49) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL12465699 | 0.77 | SSTR5 (0.33) | PTGS1PTGS2SSTR5 | |
| SCHEMBL10408115 | 0.77 | RARA (0.47) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL6144459 | 0.76 | RARA (0.41) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL6144456 | 0.76 | RARA (0.41) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL6144462 | 0.76 | RARA (0.41) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL289444 | 0.75 | RARB (0.55) | RARARARBRARGRXRACYP26A1 | |
| SCHEMBL3998188 | 0.72 | CYP26A1 (0.49) | RARARARBRARGRXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670744-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | Lupin Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104782-A1 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR | LUPIN LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |