Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13537109 | 0.81 | TYR (0.49) | TYRPTGS1MEN1PTGS2KMT2A | |
| SCHEMBL9945899 | 0.80 | TYR (0.61) | TYRPTGS1TSHRLMNAHIF1A | |
| SCHEMBL8653020 | 0.78 | ABCB11 (0.49) | ABCB11FAAHPTGS1MEN1PTGS2 | |
| SCHEMBL1349496 | 0.78 | TYR (0.44) | TYRPTGS1MEN1PTGS2KMT2A | |
| SCHEMBL12891909 | 0.78 | ABCB11 (0.49) | ABCB11FAAHPTGS1MEN1PTGS2 | |
| SCHEMBL5498418 | 0.77 | TYR (0.41) | TYRAKR1C3AKR1C2ADRA2BLMNA | |
| SCHEMBL25853230 | 0.74 | ABCB11 (0.45) | ABCB11FAAHPTGS1MEN1PTGS2 | |
| SCHEMBL2063899 | 0.73 | MT-CO2 (0.48) | TYRPTGS1MEN1PTGS2KMT2A | |
| SCHEMBL20738580 | 0.72 | ABCB11 (0.46) | ABCB11PTGS2AKR1C3AKR1C2TSHR | |
| SCHEMBL25857177 | 0.72 | ABCB11 (0.46) | ABCB11PTGS2AKR1C3AKR1C2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278969-A2 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2010011375-A2 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-01-28 | — | — | WO | disclosed |