Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 16/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304833 | 0.84 | ICMT (0.68) | ICMTMAPTALDH1A1 | |
| SCHEMBL12110882 | 0.84 | ICMT (0.68) | ICMTMAPTALDH1A1 | |
| SCHEMBL14596315 | 0.84 | ICMT (0.62) | ICMTLMNAMAPTALDH1A1GMNN | |
| SCHEMBL12466774 | 0.83 | ICMT (0.72) | ICMTMAPTALDH1A1 | |
| SCHEMBL12466742 | 0.82 | ICMT (0.69) | ICMTMAPTALDH1A1POLB | |
| SCHEMBL14596313 | 0.80 | ICMT (0.70) | ICMTMAPTALDH1A1 | |
| SCHEMBL5808346 | 0.77 | MAPT (0.77) | ICMTMAPTALDH1A1TRPA1 | |
| SCHEMBL12110880 | 0.76 | ICMT (0.61) | ICMTLMNAMAPTALDH1A1GMNN | |
| SCHEMBL12466755 | 0.76 | ICMT (0.61) | ICMTLMNAMAPTALDH1A1GMNN | |
| SCHEMBL21697821 | 0.76 | ICMT (0.67) | ICMTLMNAMAPTALDH1A1GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592173-B2 | Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 2013-11-26 | — | — | US | disclosed |
| US-20130084573-A1 | Cancer Diagnosis by Measuring Polyisoprenylated Methylated Protein Methyl Esterase Activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-04-04 | — | — | US | disclosed |
| WO-2012102773-A2 | CANCER DIAGNOSIS BY MEASURING POLYISOPRENYLATED METHYLATED PROTEIN METHYL ESTERASE ACTIVITY | FLORIDA AGRICULTURAL AND MECHANICAL UNIVERSITY (US) | 2012-08-02 | — | — | WO | disclosed |