Eucomic Acid

Eucomic Acid

SCHEMBL12466852

O=C(O)CC(O)(Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.51

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BLM P54132 1/20 0.51
ALDH1A1 P00352 1/20 0.50
SLC13A5 Q86YT5 7/20 0.49
CA2 P00918 1/20 0.48
CAMK2A Q9UQM7 1/20 0.48
ESR1 P03372 3/20 0.44
ESR2 Q92731 2/20 0.44
FNTA P49354 1/20 0.40
FNTB P49356 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eucomic Acid SCHEMBL23355983 1.00 BLM (0.51) BLMALDH1A1SLC13A5CA2CAMK2A
Citric Acid SCHEMBL2169490 0.86 ALDH1A1 (0.68) BLMALDH1A1SLC13A5CA2CAMK2A
SCHEMBL7300860 0.85 SLC13A5 (0.56) ALDH1A1SLC13A5KDM4EMEN1LMNA
Citric Acid SCHEMBL28987020 0.84 ALDH1A1 (0.54) BLMALDH1A1SLC13A5CA2CAMK2A
SCHEMBL10941763 0.83 SLC13A5 (0.54) ALDH1A1SLC13A5KDM4EMEN1LMNA
SCHEMBL5343038 0.81 BLM (0.56) BLMALDH1A1CA2CAMK2AESR1
Citric Acid SCHEMBL28803585 0.81 CA2 (0.57) ALDH1A1SLC13A5CA2CAMK2AESR1
SCHEMBL559315 0.80 CTBP2 (0.57) BLMCA2CAMK2AESR1ESR2
SCHEMBL559316 0.80 CTBP2 (0.57) BLMCA2CAMK2AESR1ESR2
SCHEMBL10088121 0.79 BLM (0.53) BLMALDH1A1SLC13A5CA2CAMK2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023145880-A1 GLUTAMINASE INHIBITOR 国立大学法人富山大学 2023-08-03 WO disclosed
US-11365170-B2 Non-solvate crystal of eucomic acid and method for producing same KYOWA HAKKO BIO CO., LTD. (JP) 2022-06-21 US disclosed
US-20210221764-A1 NON-SOLVATE CRYSTAL OF EUCOMIC ACID AND METHOD FOR PRODUCING SAME KYOWA HAKKO BIO CO., LTD. (JP) 2021-07-22 US disclosed
EP-3822249-A1 CRYSTAL OF EUCOMIC ACID NON-SOLVATE AND PRODUCTION METHOD THEREFOR Kyowa Hakko Bio Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-103003292-B Cosmetic composition 娇兰有限公司 2016-06-29 CN disclosed
CN-103003292-B Cosmetic composition 娇兰有限公司 2016-06-29 CN disclosed
US-9012414-B2 Cosmetic composition GUERLAIN (FR) 2015-04-21 US disclosed
US-9012414-B2 Cosmetic composition GUERLAIN (FR) 2015-04-21 US disclosed
US-20130157968-A1 COSMETIC COMPOSITION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2013-06-20 US disclosed
US-20130157968-A1 COSMETIC COMPOSITION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2013-06-20 US disclosed
CN-103003292-A Cosmetic composition GUERLAIN 2013-03-27 CN disclosed
CN-103003292-A Cosmetic composition GUERLAIN 2013-03-27 CN disclosed
EP-2556080-A1 COSMETIC COMPOSITION Guerlain (FR) 2013-02-13 EP disclosed
WO-2011125057-A4 COSMETIC COMPOSITION GUERLAIN (FR) 2012-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130157968-A1 COSMETIC COMPOSITION H1-0, H1-2, H1-3 BLM 4702/4885ALDH1A1 1287/4885SLC13A5 364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.