Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11902486 | 1.00 | LMNA (0.32) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL23008110 | 0.88 | MMP3 (0.32) | HDAC8MEN1KMT2A | |
| SCHEMBL11902134 | 0.85 | MEN1 (0.36) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11902192 | 0.85 | MEN1 (0.36) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11902882 | 0.79 | GHSR (0.34) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11902296 | 0.79 | GHSR (0.34) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11902791 | 0.78 | LMNA (0.35) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11902055 | 0.78 | LMNA (0.35) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL11903381 | 0.78 | LMNA (0.32) | LMNACYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL14952776 | 0.76 | MEN1 (0.34) | LMNACYP3A4GAACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103113-A1 | PYRAZINE AND IMIDAZOLIDINE DERIVATIVES AND THEIR USES TO TREAT HEPATITIS C | GILEAD PHARMASSET, LLC (US) | 2012-08-02 | — | — | WO | disclosed |