Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 14/20 | 0.81 |
| ▸ | DRD5 | P21918 | 13/20 | 0.81 |
| ▸ | DRD2 | P14416 | 12/20 | 0.81 |
| ▸ | DRD3 | P35462 | 11/20 | 0.81 |
| ▸ | DRD4 | P21917 | 9/20 | 0.81 |
| ▸ | MAOA | P21397 | 2/20 | 0.81 |
| ▸ | MAOB | P27338 | 2/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164206 | 0.97 | DRD1 (0.85) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL29391320 | 0.97 | DRD1 (0.85) | DRD1DRD5DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL165521 | 0.94 | MAOA (0.86) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL98108 | 0.90 | MAOA (1.00) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL29390912 | 0.90 | MAOA (1.00) | DRD1DRD5DRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL23501375 | 0.87 | MAOA (1.00) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL7973918 | 0.87 | DRD1 (0.71) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL4320673 | 0.85 | MAOA (0.91) | DRD1DRD5DRD2DRD3DRD4 | |
| Sulfuric Acid SCHEMBL174314 | 0.84 | DRD1 (0.65) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL28072797 | 0.82 | MAOA (0.83) | DRD1DRD5DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |