SCHEMBL12468869

SCHEMBL12468869

Fc1ccccc1Cn1ccnn1

nearest known ligand 0.70

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 9/20 0.70
ALDH1A1 P00352 4/20 0.54
KMT2A Q03164 2/20 0.54
MEN1 O00255 1/20 0.54
L3MBTL1 Q9Y468 2/20 0.49
MAPT P10636 2/20 0.49
PKM P14618 1/20 0.49
ADORA2A P29274 1/20 0.44
ADORA1 P30542 1/20 0.44
POLB P06746 2/20 0.43
KDM4E B2RXH2 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CCR1 P32246 1/20 0.41
CCR2 P41597 1/20 0.41
CYP2A13 Q16696 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29820003 1.00 CYP19A1 (0.70) CYP19A1ALDH1A1KMT2AMEN1L3MBTL1
SCHEMBL28263864 0.87 CYP19A1 (0.68) CYP19A1CCR1CCR2
SCHEMBL12468753 0.80 CYP19A1 (0.55) CYP19A1ALDH1A1POLBKDM4ECCR1
SCHEMBL6712996 0.79 CYP19A1 (0.58) CYP19A1CCR1CCR2
SCHEMBL305310 0.79 CYP19A1 (0.58) CYP19A1CCR1CCR2CYP2A13
SCHEMBL11128645 0.79 CYP19A1 (0.70) CYP19A1KMT2AMEN1L3MBTL1CYP3A4
SCHEMBL8801557 0.79 CYP19A1 (0.58) CYP19A1ALDH1A1KMT2AMEN1CCR1
SCHEMBL1281769 0.79 CYP19A1 (0.58) CYP19A1KDM4ECYP2D6CYP2C19
SCHEMBL9125316 0.79 CYP19A1 (0.58) CYP19A1KMT2AMEN1CCR1CCR2
SCHEMBL31286288 0.78 CYP19A1 (0.53) CYP19A1ALDH1A1KMT2APOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4025574-B1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS INC (US) 2025-05-07 EP disclosed
US-20250034100-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS INC (US) 2025-01-30 US disclosed
US-20240368119-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. 2024-11-07 US disclosed
US-12116354-B2 RIP1 inhibitory compounds and methods for making and using the same RIGEL PHARMACEUTICALS, INC. (US) 2024-10-15 US disclosed
EP-4248975-A2 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Rigel Pharmaceuticals, Inc. (US) 2023-09-27 EP disclosed
US-20230112865-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME MIDCAP FINANCIAL TRUST 2023-04-13 US disclosed
US-20230113841-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. 2023-04-13 US disclosed
US-11407736-B2 RIP1 inhibitory compounds and methods for making and using the same RIGEL PHARMACEUTICALS, INC. (US) 2022-08-09 US disclosed
EP-4025574-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Rigel Pharmaceuticals, Inc. (US) 2022-07-13 EP disclosed
CN-114728918-A RIP1 inhibiting compounds and methods of making and using the same 里格尔药品股份有限公司 2022-07-08 CN disclosed
EP-3788044-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME Rigel Pharmaceuticals, Inc. (US) 2021-03-10 EP disclosed
US-20210009537-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-01-14 US disclosed
US-20210002237-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-01-07 US disclosed
US-20210002236-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2021-01-07 US disclosed
US-20200407332-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. (US) 2020-12-31 US disclosed
US-10815206-B2 RIP1 inhibitory compounds and methods for making and using the same RIGEL PHARMACEUTICALS, INC. (US) 2020-10-27 US disclosed
US-20190337907-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIGEL PHARMACEUTICALS, INC. 2019-11-07 US disclosed
US-8969556-B2 Purine-based triazoles CASE WESTERN RESERVE UNIVERSITY (US) 2015-03-03 US disclosed
US-20140045866-A1 PURINE-BASED TRIAZOLES CASE WESTERN RESERVE UNIVERSITY 2014-02-13 US disclosed
WO-2012051296-A2 PURINE-BASED TRIAZOLES CASE WESTERN RESERVE UNIVERSITY (US) 2012-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240368119-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20210009537-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20230112865-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-11407736-B2 RIP1 inhibitory compounds and methods for making and using the same RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20200407332-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20210002237-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20210002236-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-12116354-B2 RIP1 inhibitory compounds and methods for making and using the same RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20140045866-A1 PURINE-BASED TRIAZOLES PNP, TK2, NME4 CYP19A1 4083/4885ALDH1A1 3400/4885KMT2A 3379/4885
US-20230113841-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20250034100-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-20190337907-A1 RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885
US-10815206-B2 RIP1 inhibitory compounds and methods for making and using the same RIPK1, RIPK2, RIPK3 CYP19A1 4673/4885ALDH1A1 4505/4885KMT2A 3696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.