Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | FPR1 | P21462 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15319529 | 0.91 | HDAC8 (0.48) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL12469011 | 0.82 | HDAC8 (0.49) | HDAC8HDAC6DDB1CRBNMEN1 | |
| SCHEMBL15552907 | 0.81 | DDB1 (0.56) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL826584 | 0.81 | DDB1 (0.56) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL6203746 | 0.81 | NOTUM (0.51) | MEN1KMT2ANPC1RAB9AMCHR1 | |
| SCHEMBL4974543 | 0.80 | HDAC8 (0.47) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL21965837 | 0.78 | DDB1 (0.52) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL21965730 | 0.78 | DDB1 (0.52) | HDAC8HDAC6DDB1CRBNROCK2 | |
| SCHEMBL15319926 | 0.76 | ALDH1A1 (0.46) | HDAC8HDAC6DDB1CRBNMEN1 | |
| SCHEMBL308869 | 0.76 | PTPN1 (0.59) | HDAC8HDAC6DDB1CRBNROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | disclosed |
| EP-2627631-A1 | PYRROLIDINONES AS METAP2 INHIBITORS | Merck Patent GmbH (DE) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012048775-A1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-04-19 | — | — | WO | disclosed |