Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15319587 | 0.96 | CASP3 (0.46) | ALDH1A1LMNANPC1CASP3HDAC8 | |
| SCHEMBL12469011 | 0.93 | HDAC8 (0.49) | ALDH1A1LMNANPC1CASP3HDAC8 | |
| SCHEMBL4974543 | 0.81 | HDAC8 (0.47) | ALDH1A1LMNANPC1HDAC8HDAC6 | |
| SCHEMBL7456455 | 0.81 | MEN1 (0.55) | ALDH1A1LMNANPC1CASP3HSD17B10 | |
| SCHEMBL15319529 | 0.80 | HDAC8 (0.48) | ALDH1A1NPC1CASP3HDAC8HDAC6 | |
| SCHEMBL5084480 | 0.78 | DDB1 (0.47) | ALDH1A1LMNANPC1CASP3HDAC8 | |
| SCHEMBL15325159 | 0.77 | MEN1 (0.54) | ALDH1A1LMNANPC1CASP3HSD17B10 | |
| SCHEMBL12469034 | 0.76 | HDAC8 (0.56) | NPC1HDAC8HDAC6DDB1CRBN | |
| SCHEMBL15374432 | 0.75 | MEN1 (0.60) | ALDH1A1LMNANPC1CASP3HSD17B10 | |
| SCHEMBL15367247 | 0.75 | MEN1 (0.60) | ALDH1A1LMNANPC1CASP3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834221-B1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2834221-A1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | Merck Patent GmbH (DE) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013149704-A1 | CYCLIC AMIDES AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-10-10 | — | — | WO | disclosed |