Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SLC6A7 | Q99884 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CKS1B | P61024 | 1/20 | 0.50 |
| ▸ | SKP1 | P63208 | 1/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FASN | P49327 | 2/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246568 | 0.84 | SIGMAR1 (0.66) | HTR2BHPGDMAPK1 | |
| SCHEMBL4298854 | 0.81 | HPGDS (0.59) | HTR2BALDH1A1POLBCKS1BSKP1 | |
| SCHEMBL4719812 | 0.80 | MAPK1 (0.77) | SLC6A7ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL3110048 | 0.79 | KMT2A (0.52) | HTR2BSLC6A7ALDH1A1TSHRHPGD | |
| SCHEMBL1938606 | 0.79 | HPGD (0.70) | ALDH1A1TSHRHPGDMAPK1POLB | |
| SCHEMBL20788243 | 0.74 | SMN1; SMN2 (0.48) | ALDH1A1HPGDPOLBL3MBTL1PRKAB2 | |
| SCHEMBL2678752 | 0.74 | HPGD (0.75) | ALDH1A1TSHRHPGDMAPK1POLB | |
| SCHEMBL10721898 | 0.73 | MAPK1 (0.85) | SLC6A7ALDH1A1TSHRHPGDMAPK1 | |
| SCHEMBL1244776 | 0.73 | LDHA (0.62) | TSHRHPGDMEN1KMT2A | |
| SCHEMBL252026 | 0.72 | HPGD (0.79) | ALDH1A1TSHRHPGDMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2286221-A2 | METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Cayman Chemical Company (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009140364-A2 | METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | CAYMAN CHEMICAL COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |