Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 6/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | CRHBP | P24387 | 1/20 | 0.71 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.71 |
| ▸ | CNR2 | P34972 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 9/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470056 | 0.97 | ACLY (0.72) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL15199355 | 0.90 | ALDH1A1 (0.72) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12469929 | 0.89 | ACLY (0.67) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12469993 | 0.89 | ACLY (0.78) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL15199396 | 0.87 | ALDH1A1 (0.69) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12470505 | 0.87 | ACLY (0.79) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12469719 | 0.85 | CNR2 (0.60) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12469970 | 0.84 | ALDH1A1 (0.74) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12469717 | 0.84 | MEN1 (0.60) | ACLYALDH1A1LMNAHTTGAA | |
| SCHEMBL12470051 | 0.84 | ACLY (0.65) | ACLYALDH1A1LMNAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217759-A1 | Sulphonamine Compounds and Methods of Making and Using Same | ZAFGEN INC. (US) | 2013-08-22 | — | — | US | claimed |
| EP-2627632-A1 | SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-08-21 | — | — | EP | claimed |
| WO-2012051318-A1 | SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-04-19 | — | — | WO | claimed |
| US-9221787-B2 | Sulphonamine compounds and methods of making and using same | ZAFGEN, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221787-B2 | Sulphonamine compounds and methods of making and using same | ZAFGEN, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221787-B2 | Sulphonamine compounds and methods of making and using same | ZAFGEN, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130217759-A1 | Sulphonamine Compounds and Methods of Making and Using Same | ZAFGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217759-A1 | Sulphonamine Compounds and Methods of Making and Using Same | ZAFGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| US-20130217759-A1 | Sulphonamine Compounds and Methods of Making and Using Same | ZAFGEN INC. (US) | 2013-08-22 | — | — | US | disclosed |
| EP-2627632-A1 | SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051318-A1 | SULPHONAMIDE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217759-A1 | Sulphonamine Compounds and Methods of Making and Using Same | DNPEP, METAP2, ANPEP | ACLY 1062/4885ALDH1A1 957/4885LMNA 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.