Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 4/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | STAT6 | P42226 | 4/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12470487 | 0.85 | MAPT (0.41) | AKR1C3METKCNH2PRKDC | |
| SCHEMBL3162336 | 0.76 | PLA2G2A (0.35) | METMAPK1 | |
| SCHEMBL1163294 | 0.70 | MET (0.44) | MET | |
| SCHEMBL18395216 | 0.66 | AKR1C3 (0.45) | AOC3AKR1C3MAPK1 | |
| SCHEMBL18394827 | 0.64 | POLB (0.48) | AKR1C3MAPK1JAK2JAK1TYK2 | |
| SCHEMBL1432612 | 0.63 | AOC3 (0.73) | AOC3 | |
| SCHEMBL18412765 | 0.63 | ALDH1A1 (0.48) | AKR1C3PRKDCMAPK1JAK2JAK1 | |
| SCHEMBL18394825 | 0.63 | TP53 (0.49) | AOC3FLT3BTK | |
| SCHEMBL28907058 | 0.63 | GSK3B (0.52) | AKR1C3SRCMAPK1JAK2JAK1 | |
| SCHEMBL24532111 | 0.63 | MEN1 (0.61) | KCNH2PRKDCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673277-A1 | [1, 2, 4]TRIAZOLO [4, 3 -B]PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE | Novartis AG (CH) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012107500-A1 | [1, 2, 4] TRIAZOLO [4, 3 -B] PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE | NOVARTIS AG (CH) | 2012-08-16 | — | — | WO | disclosed |