Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
| ▸ | GBA1 | P04062 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12444 | 0.91 | BACE1 (0.56) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL12197 | 0.88 | GBA1 (0.55) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL17269114 | 0.84 | MBTD1 (0.56) | MEN1KMT2ALTA4HSIGMAR1 | |
| SCHEMBL4512639 | 0.83 | LTA4H (0.60) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL3271398 | 0.83 | LTA4H (0.60) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL12449589 | 0.82 | MCHR1 (0.46) | LTA4HTMEM97SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL18082551 | 0.82 | LTA4H (0.55) | BCHEMEN1KMT2ABACE1ACHE | |
| Hydrochloric Acid SCHEMBL18038825 | 0.82 | LTA4H (0.58) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL18082557 | 0.82 | TMEM97 (0.48) | BCHEMEN1KMT2ABACE1ACHE | |
| SCHEMBL8212538 | 0.79 | BCHE (0.56) | BCHEMEN1KMT2ABACE1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |