Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285981 | 0.91 | SIGMAR1 (0.62) | LTA4HACHEBACE1BCHESIGMAR1 | |
| SCHEMBL12082512 | 0.90 | ALDH1A1 (0.56) | LTA4HACHEBACE1ALDH1A1LMNA | |
| SCHEMBL12311 | 0.86 | S1PR1 (0.51) | LTA4HSIGMAR1DRD4TMEM97ALDH1A1 | |
| SCHEMBL1240977 | 0.86 | LTA4H (0.54) | LTA4HACHEBACE1BCHESIGMAR1 | |
| SCHEMBL1241949 | 0.86 | LTA4H (0.54) | LTA4HACHEBACE1BCHESIGMAR1 | |
| SCHEMBL4288563 | 0.86 | LTA4H (0.54) | LTA4HSIGMAR1ALDH1A1LMNA | |
| SCHEMBL1240978 | 0.86 | LTA4H (0.54) | LTA4HACHEBACE1BCHESIGMAR1 | |
| SCHEMBL13343762 | 0.86 | LTA4H (0.54) | LTA4HSIGMAR1ALDH1A1LMNA | |
| SCHEMBL4512639 | 0.85 | LTA4H (0.60) | LTA4HACHEBACE1BCHESIGMAR1 | |
| SCHEMBL3271398 | 0.85 | LTA4H (0.60) | LTA4HACHEBACE1BCHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |