SCHEMBL124741

SCHEMBL124741

CC(F)c1ccc2cc(C(=O)O)c(C(F)(F)F)nc2n1

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GFER P55789 1/20 0.38
ALDH1A1 P00352 3/20 0.33
SORT1 Q99523 4/20 0.32
KDM4E B2RXH2 4/20 0.31
HPGD P15428 3/20 0.31
HSD17B10 Q99714 2/20 0.31
NOTUM Q6P988 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
USP2 O75604 1/20 0.31
CYP2C19 P33261 1/20 0.31
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
DHODH Q02127 1/20 0.31
ASPH Q12797 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3430681 0.89 GFER (0.38) GFERALDH1A1SORT1KDM4EHPGD
SCHEMBL126778 0.86 GFER (0.36) GFERALDH1A1SORT1KDM4EHPGD
SCHEMBL122918 0.83 KDM4E (0.48) ALDH1A1KDM4EHPGDNPSR1
SCHEMBL3431113 0.82 GFER (0.34) GFERSORT1NR1H2NR1H3
SCHEMBL125802 0.80 GFER (0.43) GFERALDH1A1SORT1KDM4ENOTUM
SCHEMBL126956 0.79 ALDH1A1 (0.39) GFERALDH1A1SORT1KDM4EHPGD
SCHEMBL122983 0.79 TAS2R14 (0.40) GFERALDH1A1KDM4EHPGDHSD17B10
SCHEMBL125060 0.78 GFER (0.39) GFERALDH1A1SORT1KDM4EHPGD
SCHEMBL125428 0.78 GFER (0.39) GFERALDH1A1SORT1KDM4EHPGD
SCHEMBL28008297 0.78 GFER (0.39) GFERALDH1A1SORT1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102006777-B Herbicidal compounds SYNGENTA LTD 2015-04-01 CN disclosed
US-8461083-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2013-06-11 US disclosed
EP-2265120-B1 HERBICIDAL COUMPOUNDS SYNGENTA LTD (GB) 2012-03-07 EP disclosed
CN-102006777-A Herbicidal coumpounds SYNGENTA LTD 2011-04-06 CN disclosed
US-20110021352-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 US disclosed
EP-2265120-A1 HERBICIDAL COUMPOUNDS Syngenta Limited (GB) 2010-12-29 EP disclosed
WO-2009115788-A1 HERBICIDAL COUMPOUNDS SYNGENTA LIMITED (GB) 2009-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021352-A1 HERBICIDAL COMPOUNDS RDX, NQO2, DDT GFER 986/4885ALDH1A1 677/4885SORT1 3099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.