SCHEMBL122983

SCHEMBL122983

O=C(O)c1cc2ccc(C(F)(F)F)nc2nc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TAS2R14 Q9NYV8 2/20 0.40
GFER P55789 1/20 0.39
DHODH Q02127 1/20 0.36
ACLY P53396 1/20 0.35
KDM4E B2RXH2 2/20 0.35
HPGD P15428 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HSD17B10 Q99714 1/20 0.35
LMNA P02545 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
ASPH Q12797 1/20 0.34
SYK P43405 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL125060 0.90 GFER (0.39) GFERDHODHKDM4EHPGDALDH1A1
SCHEMBL125802 0.83 GFER (0.43) GFERKDM4EALDH1A1LMNA
SCHEMBL124762 0.83 XPO1 (0.46) GFERDHODHKDM4EHPGDALDH1A1
SCHEMBL127078 0.83 ALDH1A1 (0.49) TAS2R14ALDH1A1LMNASYK
SCHEMBL125428 0.81 GFER (0.39) GFERKDM4EHPGDALDH1A1HSD17B10
SCHEMBL28008297 0.81 GFER (0.39) GFERKDM4EHPGDALDH1A1HSD17B10
SCHEMBL6376901 0.80 TAS2R14 (0.45) TAS2R14GFERDHODHACLYKDM4E
SCHEMBL126118 0.80 GFER (0.39) GFERKDM4EHPGDALDH1A1HSD17B10
SCHEMBL27838153 0.80 TDP1 (0.48) GFERKDM4EHPGDALDH1A1HSD17B10
SCHEMBL126502 0.80 GABRP (0.43) TAS2R14KDM4EHPGDALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102006777-B Herbicidal compounds SYNGENTA LTD 2015-04-01 CN disclosed
US-8461083-B2 Herbicidal compounds SYNGENTA LIMITED (GB) 2013-06-11 US disclosed
EP-2265120-B1 HERBICIDAL COUMPOUNDS SYNGENTA LTD (GB) 2012-03-07 EP disclosed
US-20110021352-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, INC. (US) 2011-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110021352-A1 HERBICIDAL COMPOUNDS RDX, NQO2, DDT TAS2R14 4099/4885GFER 986/4885DHODH 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.