Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984707 | 0.78 | SIGMAR1 (0.40) | L3MBTL3L3MBTL1SIGMAR1CHRM3KDM4E | |
| SCHEMBL6855187 | 0.73 | NCF1 (0.35) | TP53EPHX1 | |
| SCHEMBL930588 | 0.73 | — | — | |
| SCHEMBL1936961 | 0.72 | TP53 (0.39) | L3MBTL3L3MBTL1TP53CHRM3HRH3 | |
| SCHEMBL15088883 | 0.70 | ALDH1A1 (0.53) | L3MBTL3L3MBTL1CHRM3KDM4EHRH3 | |
| SCHEMBL13497284 | 0.70 | ALDH1A1 (0.53) | L3MBTL3L3MBTL1CHRM3KDM4EHRH3 | |
| SCHEMBL15088776 | 0.70 | ALDH1A1 (0.53) | L3MBTL3L3MBTL1CHRM3KDM4EHRH3 | |
| SCHEMBL16501529 | 0.70 | ALDH1A1 (0.41) | L3MBTL3L3MBTL1SIGMAR1CHRM3HRH3 | |
| SCHEMBL16501530 | 0.70 | ALDH1A1 (0.41) | L3MBTL3L3MBTL1SIGMAR1CHRM3HRH3 | |
| SCHEMBL16501532 | 0.70 | ALDH1A1 (0.41) | L3MBTL3L3MBTL1SIGMAR1CHRM3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611810-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES | Grünenthal GmbH (DE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028331-A1 | SUBSTITUTED TETRAHYDROPYRROLOPYRAZINE DERIVATIVES | Grünenthal GmbH (DE) | 2012-03-08 | — | — | WO | disclosed |