Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984641 | 0.76 | MAPK1 (0.41) | AKR1C3GABRA1GABRB2CA2 | |
| SCHEMBL3718724 | 0.75 | HSD11B1 (0.41) | HSD11B1AKR1C3DRD2DRD3DRD4 | |
| Methylamine SCHEMBL27336813 | 0.74 | MAPK1 (0.40) | AKR1C3GABRA1GABRB2 | |
| SCHEMBL1707740 | 0.72 | HSD11B1 (0.41) | HSD11B1AKR1C3DRD2DRD3HTR1D | |
| SCHEMBL3655498 | 0.72 | HSD11B1 (0.37) | HSD11B1DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3024960 | 0.70 | RORC (0.43) | HSD11B1DRD2DRD3DRD4DRD1 | |
| SCHEMBL3024958 | 0.70 | RORC (0.43) | HSD11B1DRD2DRD3DRD4DRD1 | |
| SCHEMBL31136597 | 0.68 | HSD11B1 (0.41) | HSD11B1DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3533741 | 0.68 | DRD2 (0.43) | AKR1C3DRD2DRD3HTR1DDRD4 | |
| SCHEMBL3533743 | 0.68 | DRD2 (0.43) | AKR1C3DRD2DRD3HTR1DDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675774-A1 | PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2013-12-25 | — | — | EP | disclosed |
| WO-2012111849-A1 | PRODUCTION METHOD OF OPTICALLY ACTIVE DIHYDROBENZOFURAN DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-08-23 | — | — | WO | disclosed |