Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR3 | P32745 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | Q9HBH1 | 1/20 | 0.43 | |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12476680 | 0.88 | HTR2A (0.45) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL18102693 | 0.81 | SSTR3 (0.51) | SSTR3PRSS1PRSS2PRSS3HDAC8 | |
| SCHEMBL12475982 | 0.81 | ALDH1A1 (0.47) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL12476207 | 0.81 | ALDH1A1 (0.47) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL15702069 | 0.80 | SSTR3 (0.51) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL18788630 | 0.80 | SSTR3 (0.65) | SSTR3HTR2APDFLTA4HPRSS1 | |
| SCHEMBL18788631 | 0.80 | SSTR3 (0.65) | SSTR3HTR2APDFLTA4HPRSS1 | |
| SCHEMBL15810831 | 0.79 | LTA4H (0.57) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A | |
| SCHEMBL15702064 | 0.79 | SSTR3 (0.52) | SSTR3ALDH1A1MAPK1L3MBTL1HDAC8 | |
| SCHEMBL16599524 | 0.79 | HTR2A (0.52) | SSTR3ALDH1A1MAPK1L3MBTL1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658981-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-11-06 | — | — | EP | disclosed |
| WO-2012089352-A1 | SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-05 | — | — | WO | disclosed |