Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL619691 | 0.83 | KDM4E (0.45) | ALDH1A1KDM4EHPGDCASP1CASP7 | |
| SCHEMBL224979 | 0.80 | MAOB (0.64) | MAOBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL31260255 | 0.80 | MAOB (0.64) | MAOBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2761874 | 0.79 | PDK2 (0.43) | MAOBALDH1A1HPGD | |
| SCHEMBL12479183 | 0.79 | MAOB (0.40) | MAOBALDH1A1HPGDHTR2C | |
| SCHEMBL11381322 | 0.76 | ALDH1A1 (0.61) | ALDH1A1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL2317705 | 0.76 | MAOB (0.59) | MAOBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL10403215 | 0.75 | MAOB (0.57) | MAOBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL10403216 | 0.75 | MAOB (0.67) | MAOBALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL20554746 | 0.75 | MAOB (0.72) | MAOBALDH1A1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |