Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2761874 | 0.79 | PDK2 (0.43) | MAOBPTGS2PDK2ALKALDH1A1 | |
| SCHEMBL12478980 | 0.79 | MAOB (0.56) | MAOBALDH1A1HPGDHTR2C | |
| SCHEMBL10610280 | 0.73 | PDK2 (0.34) | MAOBPTGS2PDK2PTGS1ALK | |
| SCHEMBL619691 | 0.73 | KDM4E (0.45) | ALDH1A1HPGDHTR2C | |
| SCHEMBL10610584 | 0.72 | PDK2 (0.35) | MAOBPTGS2PDK2ALKALDH1A1 | |
| SCHEMBL10610803 | 0.71 | PDK2 (0.34) | PDK2PTGS1ALKHRH3PRMT5 | |
| SCHEMBL12316535 | 0.70 | HPGD (0.44) | MAOBPTGS2PDK2PTGS1ALDH1A1 | |
| SCHEMBL12686425 | 0.69 | S100A4 (0.42) | MAOBPTGS2ALDH1A1 | |
| SCHEMBL12479266 | 0.69 | S100A4 (0.42) | MAOBALDH1A1HTR2C | |
| SCHEMBL12478249 | 0.69 | TGM2 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012110860-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-08-23 | — | — | WO | disclosed |