Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12484084 | 0.84 | POLB (0.40) | ACHEPOLBSMN1; SMN2MEN1TP53 | |
| SCHEMBL14844978 | 0.81 | ACHE (0.46) | ACHEPOLBTSHRSMN1; SMN2PTPN1 | |
| SCHEMBL12485888 | 0.78 | POLM (0.54) | KDM4EMEN1HTR2AKMT2AALOX15 | |
| SCHEMBL4054448 | 0.78 | INPPL1 (0.45) | POLBKDM4EALDH1A1HPGDUSP2 | |
| SCHEMBL544041 | 0.76 | ACHE (0.69) | ACHEPOLBTSHRPTPN1KDM4E | |
| SCHEMBL7033578 | 0.73 | ACHE (0.53) | ACHETSHRSMN1; SMN2PTPN1KDM4E | |
| SCHEMBL31158157 | 0.72 | CYP3A4 (0.48) | POLBTSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL742810 | 0.71 | ACHE (0.62) | ACHEPOLBTSHRPTPN1KDM4E | |
| SCHEMBL31229899 | 0.71 | ACHE (0.62) | ACHEPOLBTSHRPTPN1KDM4E | |
| SCHEMBL1445775 | 0.71 | CYP1A2 (0.40) | POLBTSHRALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678341-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM Pharma Co., Ltd. (JP) | 2014-01-01 | — | — | EP | claimed |
| WO-2012115286-A1 | ALPHA HELIX MIMETICS AND METHODS RELATING THERETO | PRISM BIOLAB CORPORATION (JP) | 2012-08-30 | — | — | WO | claimed |