Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | TEK | Q02763 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14844977 | 0.82 | PTPN1 (0.46) | ACHEPOLBPTPN1KDM4ETDP1 | |
| SCHEMBL12485236 | 0.81 | KMT2A (0.45) | POLBKDM4ESMN1; SMN2MEN1HTR2A | |
| SCHEMBL12483487 | 0.81 | ACHE (0.49) | ACHEPOLBPDE5APTPN1KDM4E | |
| SCHEMBL14844839 | 0.80 | POLM (0.49) | POLBKDM4EMEN1HTR2AKMT2A | |
| SCHEMBL12484604 | 0.80 | POLM (0.51) | KDM4EMEN1HTR2AKMT2A | |
| SCHEMBL12483491 | 0.78 | ACHE (0.46) | ACHEPOLBPDE5APTPN1KDM4E | |
| SCHEMBL27732755 | 0.74 | NUDT1 (0.40) | TDP1CYP3A4KDRTEKHSD17B10 | |
| SCHEMBL544041 | 0.73 | ACHE (0.69) | ACHEPOLBPTPN1KDM4ETDP1 | |
| SCHEMBL27913277 | 0.72 | AAK1 (0.40) | CYP3A4KDRTEKHSP90AA1CHRNA4 | |
| SCHEMBL28308750 | 0.72 | CYP2D6 (0.39) | KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763995-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | University of Southern California (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013052162-A1 | CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2013-04-11 | — | — | WO | disclosed |