Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.36 |
| ▸ | ITGAL | P20701 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12484579 | 1.00 | IMPDH2 (0.38) | IMPDH2ADORA2AADORA1ITGB2ICAM1 | |
| SCHEMBL12484641 | 0.91 | CDK2 (0.38) | ADORA2AADORA1LCKJAK3CDK1 | |
| SCHEMBL17745825 | 0.90 | ADORA2A (0.41) | IMPDH2ADORA2AADORA1TRPV1CNR2 | |
| SCHEMBL17745811 | 0.89 | LCK (0.43) | LCKJAK3TRPV1CDK4CNR2 | |
| Hydrochloric Acid SCHEMBL17745788 | 0.88 | LCK (0.42) | LCKJAK3TRPV1CDK4CNR2 | |
| SCHEMBL12484038 | 0.87 | ADORA2A (0.38) | IMPDH2ADORA2AADORA1CDK1PRKCA | |
| SCHEMBL12484034 | 0.87 | ADORA2A (0.38) | IMPDH2ADORA2AADORA1CDK1PRKCA | |
| SCHEMBL12484599 | 0.86 | ADORA2A (0.41) | IMPDH2ADORA2AADORA1CDK1PRKCA | |
| SCHEMBL12484597 | 0.86 | ADORA2A (0.41) | IMPDH2ADORA2AADORA1CDK1PRKCA | |
| SCHEMBL12485291 | 0.85 | CDK1 (0.42) | IMPDH2ADORA2AADORA1CDK1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890138-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | YUHAN CORPORATION (KR) | 2018-02-13 | — | — | US | claimed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | claimed |
| US-20150274700-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2015-10-01 | — | — | US | claimed |
| EP-2678332-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 2014-01-01 | — | — | EP | claimed |
| US-20130338179-A1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2013-12-19 | — | — | US | claimed |
| WO-2012115480-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2012-08-30 | — | — | WO | claimed |
| US-10227330-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | YUHAN CORPORATION (KR) | 2019-03-12 | — | — | US | disclosed |
| US-20180111918-A1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2018-04-26 | — | — | US | disclosed |
| US-9890138-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | YUHAN CORPORATION (KR) | 2018-02-13 | — | — | US | disclosed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | disclosed |
| US-20150274700-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2015-10-01 | — | — | US | disclosed |
| EP-2678332-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 2014-01-01 | — | — | EP | disclosed |
| US-20130338179-A1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2013-12-19 | — | — | US | disclosed |
| WO-2012115480-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274700-A2 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | HRH2, GIPR, SSTR4 | IMPDH2 691/4885ADORA2A 262/4885ADORA1 138/4885 |
| US-20130338179-A1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | HRH2, GIPR, SSTR4 | IMPDH2 691/4885ADORA2A 262/4885ADORA1 138/4885 |
| US-20180111918-A1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | HRH2, GIPR, SSTR4 | IMPDH2 691/4885ADORA2A 262/4885ADORA1 138/4885 |
| US-10227330-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | HRH2, GIPR, SSTR4 | IMPDH2 691/4885ADORA2A 262/4885ADORA1 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.