Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12485268 | 0.91 | IMPDH2 (0.41) | ADORA2AADORA1IMPDH2TRPV1CYP1A2 | |
| SCHEMBL12485265 | 0.91 | IMPDH2 (0.41) | ADORA2AADORA1IMPDH2TRPV1CYP1A2 | |
| SCHEMBL12484579 | 0.90 | IMPDH2 (0.38) | ADORA2AADORA1IMPDH2TRPV1ADORA3 | |
| SCHEMBL12484585 | 0.90 | IMPDH2 (0.38) | ADORA2AADORA1IMPDH2TRPV1ADORA3 | |
| SCHEMBL12485225 | 0.87 | ADORA2A (0.42) | ADORA2AADORA1IMPDH2CYP1A2ADORA3 | |
| SCHEMBL17745811 | 0.87 | LCK (0.43) | TRPV1SYKCNR2MAP3K12 | |
| SCHEMBL12486063 | 0.86 | ROCK2 (0.46) | ADORA2AADORA1IMPDH2CYP1A2ADORA3 | |
| SCHEMBL12486057 | 0.86 | ROCK2 (0.46) | ADORA2AADORA1IMPDH2CYP1A2ADORA3 | |
| Hydrochloric Acid SCHEMBL17745788 | 0.86 | LCK (0.42) | TRPV1SYKCNR2MAP3K12 | |
| SCHEMBL17745903 | 0.86 | ADORA2A (0.45) | ADORA2AADORA1IMPDH2CYP1A2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890138-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | YUHAN CORPORATION (KR) | 2018-02-13 | — | — | US | claimed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | claimed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | disclosed |