Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17745788 | 0.99 | LCK (0.42) | LCKJAK3MCHR1SYKSMPD3 | |
| SCHEMBL12485122 | 0.90 | LCK (0.41) | LCKJAK3MCHR1SYKHRH3 | |
| SCHEMBL12485127 | 0.90 | LCK (0.41) | LCKJAK3MCHR1SYKHRH3 | |
| SCHEMBL12484585 | 0.89 | IMPDH2 (0.38) | LCKJAK3CNR2TRPV1CDK4 | |
| SCHEMBL12484579 | 0.89 | IMPDH2 (0.38) | LCKJAK3CNR2TRPV1CDK4 | |
| SCHEMBL17745825 | 0.87 | ADORA2A (0.41) | SYKMAP3K12CNR2TRPV1 | |
| SCHEMBL17698280 | 0.87 | HTR2C (0.44) | — | |
| SCHEMBL17107359 | 0.86 | SMPD3 (0.36) | LCKJAK3MCHR1SMPD3HRH3 | |
| SCHEMBL12484566 | 0.86 | SMPD3 (0.36) | LCKJAK3MCHR1SMPD3HRH3 | |
| SCHEMBL12485263 | 0.85 | SMPD3 (0.39) | SMPD3HRH3RPS6KA2PRKD2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890138-B2 | Diaminopyrimidine derivatives and processes for the preparation thereof | YUHAN CORPORATION (KR) | 2018-02-13 | — | — | US | claimed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | claimed |
| EP-2678332-B1 | DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORP (KR) | 2016-05-18 | — | — | EP | disclosed |