Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.85 |
| ▸ | MAPT | P10636 | 6/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.84 |
| ▸ | TP53 | P04637 | 1/20 | 0.84 |
| ▸ | ATM | Q13315 | 1/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.84 |
| ▸ | MAOB | P27338 | 3/20 | 0.74 |
| ▸ | MAOA | P21397 | 2/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.68 |
| ▸ | DPP4 | P27487 | 1/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.68 |
| ▸ | RELA | Q04206 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12485774 | 1.00 | ABCG2 (0.85) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL29439356 | 0.92 | MAPT (1.00) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL1938260 | 0.92 | MAPT (1.00) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL1675987 | 0.92 | MAPT (1.00) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL30382640 | 0.92 | MAPT (1.00) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL25185055 | 0.92 | MAPT (1.00) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL25193713 | 0.90 | MAPT (0.97) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL25265211 | 0.90 | MAPT (0.97) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| Flavokawain B SCHEMBL30384635 | 0.90 | MAPT (0.97) | ABCG2MAPTKMT2ACYP3A4TP53 | |
| 4,2',4',6'-Tetramethoxychalcone SCHEMBL633892 | 0.89 | ABCG2 (0.94) | ABCG2MAPTKMT2ACYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| US-20140088052-A1 | CHALCONE DERIVATIVES AS NRF2 ACTIVATORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-03-27 | — | — | US | disclosed |
| WO-2012116362-A2 | CHALCONE DERIVATIVES AS NRF2 ACTIVATORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088052-A1 | CHALCONE DERIVATIVES AS NRF2 ACTIVATORS | NFE2L2, NFE2, KEAP1 | ABCG2 3815/4885MAPT 3465/4885KMT2A 4089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.