Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.62 |
| ▸ | PHLPP2 | Q6ZVD8 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 1/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486693 | 1.00 | RPS6KA3 (0.62) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL8844931 | 0.89 | RPS6KA3 (0.64) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL8844924 | 0.89 | RPS6KA3 (0.64) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL11242221 | 0.87 | BRD4 (0.64) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL11242226 | 0.87 | BRD4 (0.64) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL6123730 | 0.84 | RPS6KA3 (0.54) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL14004211 | 0.84 | RPS6KA3 (0.54) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL12758032 | 0.84 | RPS6KA3 (0.54) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL7813054 | 0.83 | RPS6KA3 (0.63) | RPS6KA3PHLPP2POLBCYP2D6BRD4 | |
| SCHEMBL7813050 | 0.83 | RPS6KA3 (0.63) | RPS6KA3PHLPP2POLBCYP2D6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-06 | — | — | US | disclosed |
| EP-2677865-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | Icahn School of Medicine at Mount Sinai (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012116170-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | ZHOU MING-MING (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066410-A1 | INHIBITORS OF BROMODOMAINS AS MODULATORS OF GENE EXPRESSION | NFKBIA, NFKB2, IKBKG | RPS6KA3 1654/4885PHLPP2 1158/4885POLB 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.