Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.79 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | MPO | P05164 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.60 |
| ▸ | FPR2 | P25090 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12486443 | 0.89 | PRMT5 (0.69) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12486391 | 0.84 | MPO (1.00) | PRMT5WDR77ALDH1A1LMNAMPO | |
| SCHEMBL6210308 | 0.83 | KCNH2 (0.84) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12485915 | 0.83 | KCNH2 (0.80) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12486403 | 0.80 | MAPT (0.77) | PRMT5WDR77ALDH1A1LMNAMPO | |
| SCHEMBL12487081 | 0.80 | KCNH2 (1.00) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12485902 | 0.78 | KCNH2 (0.75) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12487161 | 0.78 | KCNH2 (0.75) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12486442 | 0.78 | KCNH2 (0.75) | PRMT5WDR77ALDH1A1LMNAKCNH2 | |
| SCHEMBL12486533 | 0.76 | THRB (0.72) | PRMT5WDR77ALDH1A1LMNAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-03-06 | — | — | US | claimed |
| EP-2678319-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | The General Hospital Corporation (US) | 2014-01-01 | — | — | EP | claimed |
| WO-2012116010-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-08-30 | — | — | WO | claimed |
| US-20150266827-A1 | Antibiotic Tolerance Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2015-09-24 | — | — | US | disclosed |
| US-8877940-B2 | Antibiotic tolerance inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-11-04 | — | — | US | disclosed |
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-03-06 | — | — | US | disclosed |
| EP-2678319-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | The General Hospital Corporation (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012116010-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266827-A1 | Antibiotic Tolerance Inhibitors | CLPP, CFTR, AADAC | PRMT5 3247/4885WDR77 4706/4885ALDH1A1 1458/4885 |
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | CLPP, CFTR, AADAC | PRMT5 3247/4885WDR77 4706/4885ALDH1A1 1458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.