Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 5/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184601 | 0.93 | MAPT (0.64) | MAPTALDH1A1POLBKCNH2LMNA | |
| SCHEMBL12485902 | 0.83 | KCNH2 (0.75) | MAPTALDH1A1KCNH2LMNAMAPK1 | |
| SCHEMBL12486442 | 0.83 | KCNH2 (0.75) | MAPTALDH1A1KCNH2LMNAMAPK1 | |
| SCHEMBL12487161 | 0.83 | KCNH2 (0.75) | MAPTALDH1A1KCNH2LMNAMAPK1 | |
| SCHEMBL12486403 | 0.83 | MAPT (0.77) | MAPTALDH1A1POLBKCNH2LMNA | |
| SCHEMBL6210308 | 0.83 | KCNH2 (0.84) | MAPTALDH1A1POLBKCNH2LMNA | |
| SCHEMBL12486533 | 0.80 | THRB (0.72) | MAPTALDH1A1KCNH2LMNAMAPK1 | |
| SCHEMBL12485915 | 0.80 | KCNH2 (0.80) | MAPTALDH1A1POLBKCNH2LMNA | |
| SCHEMBL16208427 | 0.80 | MAPT (0.69) | MAPTALDH1A1POLBLMNAMAPK1 | |
| SCHEMBL20679555 | 0.80 | ALDH1A1 (0.66) | MAPTALDH1A1POLBLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-03-06 | — | — | US | claimed |
| EP-2678319-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | The General Hospital Corporation (US) | 2014-01-01 | — | — | EP | claimed |
| WO-2012116010-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-08-30 | — | — | WO | claimed |
| US-20150266827-A1 | Antibiotic Tolerance Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2015-09-24 | — | — | US | disclosed |
| US-8877940-B2 | Antibiotic tolerance inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-11-04 | — | — | US | disclosed |
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) | 2014-03-06 | — | — | US | disclosed |
| EP-2678319-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | The General Hospital Corporation (US) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012116010-A2 | ANTIBIOTIC TOLERANCE INHIBITORS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266827-A1 | Antibiotic Tolerance Inhibitors | CLPP, CFTR, AADAC | MAPT 3775/4885ALDH1A1 1458/4885POLB 1761/4885 |
| US-20140066454-A1 | Antibiotic Tolerance Inhibitors | CLPP, CFTR, AADAC | MAPT 3775/4885ALDH1A1 1458/4885POLB 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.