Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21465773 | 0.89 | CYP2D6 (0.46) | ABL1RIN1CYP2D6ALDH1A1MEN1 | |
| SCHEMBL1618300 | 0.86 | NR3C1 (0.48) | CYP2D6ALDH1A1KMT2AOPRM1NR3C1 | |
| SCHEMBL2237372 | 0.81 | NR3C1 (0.45) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15498515 | 0.79 | LMNA (0.46) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL15710575 | 0.78 | KDM4E (0.50) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL11307926 | 0.76 | GAA (0.48) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL17239738 | 0.75 | KDM4E (0.47) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL5265862 | 0.74 | CYP2D6 (0.44) | CYP2D6ALDH1A1MEN1KMT2ANR3C1 | |
| SCHEMBL5265856 | 0.74 | CYP2D6 (0.44) | CYP2D6ALDH1A1MEN1KMT2ANR3C1 | |
| SCHEMBL4541512 | 0.74 | KDM4E (0.46) | CYP2D6ALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259796-B2 | Oxaspiro[2.5]octane derivatives and analogs | ZAFGEN, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20180354924-A1 | Oxaspiro[2.5]Octane Derivatives and Analogs | ZAFGEN INC (US) | 2018-12-13 | — | — | US | disclosed |
| EP-2683706-B1 | OXASPIRO [2.5]OCTANE DERIVATIVES AND ANALOGS | ZAFGEN INC (US) | 2018-02-21 | — | — | EP | disclosed |
| US-20170044122-A1 | Oxaspiro[2.5]Octane Derivatives and Analogs | ZAFGEN, INC. (US) | 2017-02-16 | — | — | US | disclosed |
| CN-103534244-B | Oxaspiro [2.5] Octane derivatives and the like | 扎夫根股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-103534244-A | Oxaspiro [2.5] octane derivatives and analogs | ZAFGEN CORP | 2014-01-22 | — | — | CN | disclosed |
| EP-2683706-A1 | OXASPIRO [2.5]OCTANE DERIVATIVES AND ANALOGS | Zafgen, Inc. (US) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012122264-A1 | OXASPIRO [2.5] OCTANE DERIVATIVES AND ANALOGS | ZAFGEN CORPORATION (US) | 2012-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10259796-B2 | Oxaspiro[2.5]octane derivatives and analogs | OXER1, ACOX3, OXGR1 | ABL1 4738/4885RIN1 4808/4885CYP2D6 354/4885 |
| US-20170044122-A1 | Oxaspiro[2.5]Octane Derivatives and Analogs | OXER1, ACOX3, OXGR1 | ABL1 4738/4885RIN1 4808/4885CYP2D6 354/4885 |
| US-20180354924-A1 | Oxaspiro[2.5]Octane Derivatives and Analogs | OXER1, ACOX3, OXGR1 | ABL1 4738/4885RIN1 4808/4885CYP2D6 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.