Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.58 |
| ▸ | TAS1R2 | Q8TE23 | 6/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MMP14 | P50281 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251606 | 0.94 | DGAT1 (0.56) | TAS1R3TAS1R1TAS1R2DGAT1CHEK2 | |
| SCHEMBL11407426 | 0.94 | DGAT1 (0.56) | TAS1R3TAS1R1TAS1R2DGAT1CHEK2 | |
| SCHEMBL1251024 | 0.81 | DGAT1 (0.62) | DGAT1CHEK2LMNASMN1; SMN2MAPK1 | |
| SCHEMBL1250990 | 0.80 | DGAT1 (0.65) | DGAT1CHEK2 | |
| SCHEMBL1250265 | 0.76 | DGAT1 (0.58) | DGAT1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL1251605 | 0.76 | DGAT1 (0.73) | DGAT1CHEK2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1248742 | 0.76 | DGAT1 (0.73) | DGAT1CHEK2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3393778 | 0.75 | HTT (0.64) | TAS1R3TAS1R1TAS1R2ALDH1A1LMNA | |
| SCHEMBL3389867 | 0.75 | HTT (0.64) | TAS1R3TAS1R1TAS1R2ALDH1A1LMNA | |
| SCHEMBL3394421 | 0.75 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | TAS1R3 1787/4885TAS1R1 1284/4885TAS1R2 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.