Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.57 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23099746 | 0.88 | SIGMAR1 (0.49) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL16312822 | 0.80 | SIGMAR1 (0.61) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL20627066 | 0.78 | SIGMAR1 (0.49) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL19370719 | 0.77 | SMN1; SMN2 (0.46) | SIGMAR1TAAR1SLC18A2NPC1RAB9A | |
| SCHEMBL3379120 | 0.75 | SIGMAR1 (0.65) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL3379115 | 0.75 | SIGMAR1 (0.65) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL9912493 | 0.74 | TDP1 (0.42) | CYP3A4TSHR | |
| SCHEMBL21243273 | 0.74 | SIGMAR1 (0.73) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL30624762 | 0.74 | SIGMAR1 (0.71) | SIGMAR1TAAR1SLC18A2MEN1KMT2A | |
| SCHEMBL30949882 | 0.74 | SIGMAR1 (0.56) | SIGMAR1TAAR1SLC18A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012122412-A2 | COMPOSITIONS FOR REDUCING RISK OF ADVERSE EVENTS CAUSED BY DRUG-DRUG INTERACTIONS | SIGNATURE THERAPEUTICS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |