Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.62 |
| ▸ | NR2E3 | Q9Y5X4 | 5/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.59 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | MMP9 | P14780 | 2/20 | 0.58 |
| ▸ | MMP8 | P22894 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1249179 | 0.91 | CHEK2 (0.70) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1250180 | 0.89 | CHEK2 (0.66) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1250057 | 0.88 | ATM (0.66) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1249315 | 0.87 | MEN1 (0.66) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1250299 | 0.87 | HDAC6 (0.67) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL30667663 | 0.86 | ALDH1A1 (0.72) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL12296724 | 0.86 | ALDH1A1 (0.72) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1250932 | 0.85 | CHEK2 (0.57) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL27202537 | 0.84 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDMEN1TP53 | |
| SCHEMBL1249380 | 0.83 | DGAT1 (0.67) | KDM4EALDH1A1HPGDMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | KDM4E 4129/4885ALDH1A1 44/4885HPGD 3538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.