Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 19/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 19/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 19/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 19/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 19/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 19/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12494150 | 0.83 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12494148 | 0.83 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493845 | 0.82 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6887643 | 0.73 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1570397 | 0.72 | SLC6A2 (0.56) | — | |
| SCHEMBL29437144 | 0.70 | L3MBTL1 (0.49) | — | |
| SCHEMBL27476727 | 0.70 | L3MBTL1 (0.49) | — | |
| SCHEMBL12493641 | 0.70 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14857298 | 0.70 | RAB9A (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8081931 | 0.69 | NPC1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012125622-A1 | SUBSTITUTED ADIPIC ACID AMIDES AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-09-20 | — | — | WO | disclosed |