Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 14/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831445 | 0.87 | PTGIR (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493641 | 0.77 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12493845 | 0.73 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12494089 | 0.73 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23911957 | 0.71 | SMN1; SMN2 (0.41) | ALDH1A1 | |
| SCHEMBL6613398 | 0.69 | CRBN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613354 | 0.69 | APOL1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613347 | 0.69 | APOL1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6613404 | 0.69 | CRBN (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12494295 | 0.69 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092168-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2004-10-28 | — | — | WO | disclosed |