Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.39 |
| ▸ | SPAST | Q9UBP0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20975373 | 0.84 | KDM4E (0.46) | TP53NPC1RAB9AAPAF1CASP3 | |
| SCHEMBL12495119 | 0.83 | HTR2C (0.41) | HTR2CSPASTMAPTHTR2AHTR2B | |
| SCHEMBL2871462 | 0.75 | ALDH1A1 (0.40) | MAPTTP53NPC1RAB9AAPAF1 | |
| SCHEMBL4912320 | 0.75 | MAPT (0.36) | HTR2CSPASTMAPTHTR2ATP53 | |
| SCHEMBL5667529 | 0.73 | SPAST (0.43) | HTR2CSPASTMAPTHTR2ATP53 | |
| SCHEMBL7916401 | 0.73 | ADORA2A (0.43) | MAPTTP53NPC1RAB9AAPAF1 | |
| SCHEMBL7916437 | 0.72 | ALDH1A1 (0.38) | MAPTTP53NPC1RAB9AAPAF1 | |
| SCHEMBL5667956 | 0.72 | SPAST (0.43) | HTR2CSPASTMAPTHTR2ATP53 | |
| SCHEMBL7913463 | 0.72 | ALDH1A1 (0.37) | MAPTTP53NPC1RAB9AKDM4E | |
| SCHEMBL7914416 | 0.72 | ALDH1A1 (0.40) | MAPTTP53NPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018163051-A1 | METHODS OF TREATMENT OF CANCER WITH REDUCED UBB EXPRESSION | NOVARTIS AG (CH) | 2018-09-13 | — | — | WO | disclosed |
| EP-2968592-A2 | ANTIBODY DRUG CONJUGATES | Novartis AG (CH) | 2016-01-20 | — | — | EP | disclosed |
| EP-2922572-A1 | USE OF SMALL MOLECULE INHIBITORS/ACTIVATORS IN COMBINATION WITH (DEOXY)NUCLEOSIDE OR (DEOXY)NUCLEOTIDE ANALOGS FOR TREATMENT OF CANCER AND HEMATOLOGICAL MALIGNANCIES OR VIRAL INFECTIONS | AB Science (FR) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014160160-A2 | ANTIBODY DRUG CONJUGATES | NOVARTIS AG (CH) | 2014-10-02 | — | — | WO | disclosed |
| WO-2014079709-A1 | USE OF SMALL MOLECULE INHIBITORS/ACTIVATORS IN COMBINATION WITH (DEOXY)NUCLEOSIDE OR (DEOXY)NUCLEOTIDE ANALOGS FOR TREATMENT OF CANCER AND HEMATOLOGICAL MALIGNANCIES OR VIRAL INFECTIONS | AB SCIENCE (FR) | 2014-05-30 | — | — | WO | disclosed |
| EP-2686429-A1 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS AND METHOD OF TREATING INFLAMMATORY DISEASES | Cellworks Research India Private Limited (IN) | 2014-01-22 | — | — | EP | disclosed |
| WO-2012125379-A1 | COMPOSITIONS, PROCESS OF PREPARATION OF SAID COMPOSITIONS AND METHOD OF TREATING INFLAMMATORY DISEASES | CELLWORKS RESEARCH INDIA PRIVATE LIMITED (IN) | 2012-09-20 | — | — | WO | disclosed |